Our Mission

2N Pharma was founded in 2019 to build on a decade of research undertaken by our co-founder and CSO Dr. John Nieland and his associates. While the challenge ahead is immense, our aim is clear: we want to cure ALS.

We make this bold statement well knowing that brilliant scientists have had very limited success in developing disease modifying drugs, despite many decades of research. But we believe our novel approach to treating neurological disorders will be the departure from conventional neuroscience that is required to finally make significant progress towards a cure for ALS.

2N Pharma at BII

2N Pharma has joined the BioInnovation Institute (BII) in Copenhagen, Denmark, an international initiative by the Novo Nordisk Foundation to support life science startups in bringing interdisciplinary ideas to life and research to market.

Support embraces every phase of a life-science start-up and is giving us access to high-level mentoring and international networks that will accelerate our speed to market of therapeutic drugs.

Team Members

Preben Bruun-Nyzell

CEO and Co-Founder

Preben Bruun-Nyzell is an executive with more than 20 years international experience. In addition to his role in 2N Pharma, he is co-founder and CEO of the clinical stage vaccine company 2A Pharma and chairman of Apoglyx which specialises in medical applications of aquaporin inhibitors.

John Nieland, PhD

CSO and Co-Founder

Dr. Nieland brings broad management experience, an in-depth research background and expertise in the development of biopharmaceuticals and coordination and development of clinical trials. He was previously director of research at Medigene AG and is co-founder of the clinical stage vaccine company 2A Pharma and two other biotech companies.

Anne Skøttrup Mørkholt, PhD

Project Manager

Dr. Mørkholt completed her doctorate at the Laboratory of Metabolism Modifying Medicine, Aalborg University with research into the connection between dysfunction of the lipid metabolism and CNS diseases, including multiple sclerosis and depression.

Steinunn Sara Helgudóttir, Project Manager

Steinunn Sara Helgudóttir

Project Manager

Steinunn Sara Helgudóttir has handed in her PhD thesis after conducting research in the Neurobiology Research and Drug Delivery Group at Aalborg University mainly focusing on the pathological blood-brain barrier and drug delivery. The PhD defence is expected in Q2, 2021.

Kirsten Egelund Holgaard, MSc


Kirsten Egelund Holgaard holds a Bachelor of Industrial Medicine and a Master of Biomedicine with a master’s thesis on immunohistochemical assessment of effectiveness of Carnitine Palmitoyl Transferase 1 (CPT1) blocking in rat model of experimental autoimmune encephalitis (EAE).

Pam Huntjens

Ass. Scientist

Pam Huntjens is a medical student at Aalborg University and works part-time as a research assistant.

Collaborators & Advisors

Angelique Corthals, MD, PhD

Scientific Advisor

Dr. Corthals is a biomedical researcher who has published on the connection between metabolic dysfunction and neurological disorders. She is Associate Professor at City University of New York and holds a DPhil (PhD) from the University of Oxford.

Kathryn Edson, PhD

Clinical Development Advisor

Dr. Edson is a neuroscientist with decades of drug development experience from Novartis and as an independent drug development consultant.

Michael Sloth Trabjerg, MD, PhD

Scientific Advisor

Dr. Trabjerg is a Medical Doctor and completed his PhD at the Laboratory of Metabolism Modifying Medicine, Aalborg University with research into CPT1 as a potential target to restore dysregulated metabolism in neurodegenerative diseases.

Thomas Brimert, PhD

Medicinal Chemistry Advisor

Received a PhD in organic chemistry from the Royal Institute of Technology in Stockholm. During his 11 years at AstraZeneca R&D Lund, he gained considerable medicinal chemistry experience. He has contributed to successfully delivered clinical candidates in kinase, protease and receptor projects within the respiratory & inflammation therapy area.

During his post-doc with Prof. Jan Becher at the University of Odense in Denmark, he developed new synthetic methods to supramolecular building blocks. Thomas is co-author of 8 scientific publications and 8 patents.